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    1. 技術支持


      來源期刊:未知    ALL

      A novel platform using homobifunctional hydrazide for enrichment and isolation of urinary circulating RNAs

      來源期刊:Bioengineering & Translational Medicine    mimics

      E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry

      來源期刊:International Journal of Biological Sciences    

      RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma

      來源期刊:International Journal of Biological Sciences    

      Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner

      來源期刊:Redox Biology    干擾腺病毒載體

      The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis

      來源期刊:Redox Biology    pcDNA3.1 vector

      circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA


      NCAPD3 enhances Warburg effect through c-myc and E2F1 and promotes the occurrence and progression of colorectal cancer


      Essential role for STAT3/FOXM1/ATG7 signaling-dependent autophagy in resistance to Icotinib


      Upregulating microRNA-210 to Inhibit Apoptosis of Neural Stem Cells with an MRI–Visible Nanomedicine for Stroke Therapy

      來源期刊:Small Structures    

      Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression


      TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis

      來源期刊:EMBO JOURNAL    siRNAs,LV

      ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation

      來源期刊:EMBO JOURNAL    siRNAs

      Arterial cyclic stretch regulates Lamtor1 and promotes neointimal hyperplasia via circSlc8a1/miR-20a-5p axis in vein grafts

      來源期刊:Theranostics    siRNAs

      MiR-155 deficiency protects renal tubular epithelial cells from telomeric and genomic DNA damage in cisplatin-induced acute kidney injury

      來源期刊:Theranostics    FISH probes

      Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR-135b-3p/TOX3 axis


      Regulation of mesenchymal stem cell osteogenic potential via microfluidic manipulation of microcarrier surface curvature


      A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects

      來源期刊:MOLECULAR PSYCHIATRY    probe

      Nanoparticle delivery of miR-21-3p sensitizes melanoma to anti-PD-1 immunotherapy by promoting ferroptosis

      來源期刊:Journal for ImmunoTherapy of Cancer    熒光素酶報告載體、空載

      GATA3/long noncoding RNA MHC-R regulates the immune activity of dendritic cells in chronic obstructive pulmonary disease induced by air pollution particulate matter


      Bile duct ligation differently regulates protein expressions of organic cation transporters in intestine, liver and kidney of rats through activation of farnesoid X receptor by cholate and bilirubin

      來源期刊:Acta Pharmaceutica Sinica B    siRNA

      Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase

      來源期刊:Acta Pharmaceutica Sinica B    siRNAs

      The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers

      來源期刊:Nature Communications    siRNAs

      Hierarchical Accumulation of Histone Variant H2A.Z Regulates Transcriptional States and Histone Modifications in Early Mammalian Embryos

      來源期刊:Advanced Science    siRNAs

      Dynamic Chromatin States Coupling with Key Transcription Factors in Colitis-Associated Colorectal Cancer

      來源期刊:Advanced Science    siRNAs

      ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription

      來源期刊:Nature Communications    siRNAs

      circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop

      來源期刊:Molecular Cancer    siRNAs

      METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer


      Cell fate determining molecular switches and signaling pathways in Pax7-expressing somitic mesoderm

      來源期刊:Cell Discovery    siRNA

      CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA

      來源期刊:Molecular Cancer    FISH probes

      circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer

      來源期刊:Molecular Cancer    siRNAs

      Therapeutic nucleus-access BNCT drug combined CD47-targeting gene editing in glioblastoma

      來源期刊:Journal Of Nanobiotechnology    質粒

      Visualization of the process of a nanocarrier-mediated gene delivery: stabilization, endocytosis and endosomal escape of genes for intracellular spreading

      來源期刊:Journal Of Nanobiotechnology    siRNA

      PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles

      來源期刊:Journal Of Nanobiotechnology    siRNA

      Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM

      來源期刊:Journal Of Nanobiotechnology    siRNAs

      Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer

      來源期刊:Journal Of Nanobiotechnology    siRNA

      The proteasome-dependent degradation of ALKBH5 regulates ECM deposition in PM2.5 exposure-induced pulmonary fibrosis of mice

      來源期刊:Journal Of Hazardous Materials    miRNA mimic

      ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis

      來源期刊:Cell Discovery    siRNA

      Tumor bud-derived CCL5 recruits fibroblasts and promotes colorectal cancer progression via CCR5-SLC25A24 signaling

      來源期刊:Journal Of Experimental & Clinical Cancer Research    siRNAs

      PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition

      來源期刊:Journal Of Experimental & Clinical Cancer Research    siRNAs

      PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p

      來源期刊:Journal Of Experimental & Clinical Cancer Research    siRNAs

      Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma

      來源期刊:Journal Of Experimental & Clinical Cancer Research    siRNA

      Histone methyltransferase Smyd2 contributes to blood-brain barrier breakdown in stroke

      來源期刊:Clinical and Translational Medicine    siRNA

      AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages

      來源期刊:Theranostics    siRNAs

      SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway

      來源期刊:Redox Biology    PCR引物, siRNA

      Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy


      TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p axis

      來源期刊:Biomaterials    antagomir

      mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a

      來源期刊:Bone Research    siRNAs

      The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis

      來源期刊:Bioactive Materials    干擾慢病毒

      Up-regulated YB-1 protein promotes glioblastoma growth through an YB-1/CCT4/mLST8/mTOR pathway

      來源期刊:Journal Of Clinical Investigation    RNA decoys

      A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer

      來源期刊:Journal Of Clinical Investigation    siRNAs

      An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression

      來源期刊:Nature Communications    siRNAs

      Secondary structure prediction for RNA sequences including N6-methyladenosine

      來源期刊:Nature Communications    RNA phosphoramidites

      RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection

      來源期刊:Nature Communications    RNA oligonucleotides

      Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury

      來源期刊:Cell Death And Differentiation    

      Regulation of Semaphorin3A in the process of cutaneous wound healing

      來源期刊:Cell Death And Differentiation    ADV質粒載體

      TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss

      來源期刊:Autophagy    LV,siRNA

      Engineered EGCG-Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer Therapy

      來源期刊:Advanced Science    siRNA

      RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13

      來源期刊:Advanced Science    siRNAs

      Telomerase RNA TERC and the PI3K-AKT pathway form a positive feedback loop to regulate cell proliferation independent of telomerase activity

      來源期刊:Nucleic Acids Research    siRNAs

      Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

      來源期刊:Molecular Cell    siRNA

      Tumour-derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour-homing and intracellular freeway transportation

      來源期刊:Journal of Extracellular Vesicles    siRNA

      Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma

      來源期刊:Molecular Cancer    miRNA mimic,FISH kit

      Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock

      來源期刊:Nature Cell Biology    siRNA

      Recycling of autophagosomal components from autolysosomes by the recycler complex

      來源期刊:Nature Cell Biology    siRNA

      Local hyperthermia therapy induces browning of white fat and treats obesity

      來源期刊:Cell    siRNA







      2018-siRNA Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation


      2018-siRNA PCR kit Hyperglycaemia-induced miR-301a promotes cell proliferation by repressing p21 and Smad4 in prostate cancer


      2018-siRNA Lysosomal deposition of copper oxide nanoparticles triggers HUVEC cells death


      2018-LncRNA NCK1-AS1 promotes proliferation and induces cell progression by crosstalk NCK1-AS1 miR-6857 CDK1 pathway


      2018-siRNA A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption


      2018-LV The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species


      2017-Bioreducible Cross-Linked Hyaluronic Acid Calcium Phosphate Hybrid Nanoparticles for Specific Delivery of siRNA in Melanoma Tumor Therapy


      2017 Combining Fluorination and Bioreducibility for Improved siRNA Polyplex Delivery


      2016-NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1


      2015-PAQR3 modulates cholesterol homeostasis by anchoring Scap SREBP complex to the Golgi apparatus


      2015-nature communications-APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p (antagomir)


      2015-miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program


      2015-Journal of Hepatology


      2014-Nat Cell Biol-FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement


      2014-Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus


      2014-Cancer Res-miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM


      2013-Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma


      2013-Nature biotechnology-Efficient and specific gene knockdown by small interfering RNAs produced in bacteria


      2012-cell research-Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice (antagomir)


      2011-Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth